Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae .
Shiwei LiangHuijun CaoYing FeiChenchen ZhangPublished in: Infection and drug resistance (2022)
The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by Klebsiella pneumoniae (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.
Keyphrases
- klebsiella pneumoniae
- multidrug resistant
- drug resistant
- escherichia coli
- acinetobacter baumannii
- end stage renal disease
- ejection fraction
- newly diagnosed
- cystic fibrosis
- liver failure
- chronic kidney disease
- staphylococcus aureus
- peritoneal dialysis
- prognostic factors
- genome wide
- respiratory failure
- drug induced
- single cell
- intensive care unit
- dna methylation
- adipose tissue
- climate change
- transcription factor
- antimicrobial resistance
- cell free
- glycemic control
- genome wide identification
- acute respiratory distress syndrome
- weight loss