Frontiers in Halogen and Chalcogen-Bond Donor Organocatalysis.

Non-covalent molecular interactions on the basis of halogen and chalcogen bonding represent a promising, powerful catalytic activation mode. However, these "unusual" non-covalent interactions are typically employed in the solid state and scarcely exploited in catalysis. In recent years, an increased interest in halogen and chalcogen bonding has been awaken, as they provide profound characteristics that make them an appealing alternative to the well-explored hydrogen bonding. Being particularly relevant in the binding of "soft" substrates, the similar strength to hydrogen bonding interactions and its higher directionality allows for solution-phase applications with halogen and chalcogen bonding as the key interaction. In this mini-review, the special features, state-of-the-art and key examples of these so-called σ-hole interactions in the field of organocatalysis are presented.