Enhanced polygenic risk score incorporating gene-environment interaction suggests the association of major depressive disorder with cardiac and lung function.
Chuyu PanBolun ChengXiaoyue QinShiqiang ChengLi LiuXuena YangPeilin MengHuijie ZhangDan HeQingqing CaiWenming WeiJingni HuiYan WenYumeng JiaHuan LiuFeng ZhangPublished in: Briefings in bioinformatics (2024)
Our findings underscore the profound impact of depression on cardiac and lung function, highlighting the enhanced efficacy of considering gene-environment interactions in PRS-based studies.
Keyphrases
- lung function
- major depressive disorder
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- bipolar disorder
- left ventricular
- copy number
- genome wide
- genome wide identification
- depressive symptoms
- heart failure
- dna methylation
- gene expression
- autism spectrum disorder
- case control
- atrial fibrillation