Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells.

Jie ZhuJosé Á Rodríguez-CorralesReece PrussinZongmin ZhaoAnthony DominijanniSamantha L HopkinsBrenda S J WinkelJohn L RobertsonKaren J Brewer

Published in: Chemical communications (Cambridge, England) (2017)

The mixed-metal supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.

Keyphrases

visible light
energy transfer
oxidative stress
circulating tumor
single molecule
cell free
radiation induced
water soluble