Perspectives for therapy of treatment-resistant depression.
Mariusz PappWiesław Jerzy CubałaLukasz SwiecickiAdrian Newman-TancrediPaul WillnerPublished in: British journal of pharmacology (2021)
A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments, including deep brain stimulation (DBS) and ketamine, been discovered that provide rapid and sometimes prolonged relief to a high proportion of TRD sufferers. In this review, we consider the current status of TRD from four perspectives: the challenge of developing an appropriate regulatory framework for novel rapidly acting antidepressants; the efficacy of non-pharmacological somatic therapies; the development of an animal model of TRD and its use to understand the neural basis of antidepressant non-response; and the potential for rapid antidepressant action from targets (such as 5-HT1A receptors) beyond the glutamate receptor.
Keyphrases
- deep brain stimulation
- major depressive disorder
- parkinson disease
- bipolar disorder
- end stage renal disease
- current status
- sleep quality
- obsessive compulsive disorder
- depressive symptoms
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- gene expression
- transcription factor
- emergency department
- stem cells
- patient reported outcomes
- copy number
- quantum dots
- dna methylation
- human health
- adverse drug
- risk assessment