Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.
Neil MurphyMingyang SongNikos PapadimitriouRobert Carreras-TorresClaudia LangenbergRichard M MartinKonstantinos K TsilidisInês BarrosoJi ChenTimothy M FraylingCaroline J BullEmma E VincentMichelle CotterchioStephen B GruberRish K PaiPolly A NewcombAurora Perez-CornagoFranzel J B van DuijnhovenBethany Van GuelpenPavel VodickaAlicja WolkAnna H WuUlrike PetersAndrew T ChanMarc J GunterPublished in: Journal of the National Cancer Institute (2022)
Our results support a causal effect of higher fasting insulin, but not glucose traits or type 2 diabetes, on increased colorectal cancer risk. This suggests that pharmacological or lifestyle interventions that lower circulating insulin levels may be beneficial in preventing colorectal tumorigenesis.