Establishment of a Diamond-Blackfan anemia like model in zebrafish.

Yiming LingJiaye WuYushi LiuPanpan MengYing SunDejian Zhao Qing Lin

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)

Together, our study demonstrated that epoa deficiency in zebrafish leads to a phenotype resembling DBAL. The DBAL zebrafish model was found to be beneficial for the in vivo assessment of patient-derived EPO variants with unclear implications and for devising potential therapeutic approaches for DBAL.

Keyphrases

copy number
gene expression