The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline.
Marjan KerkhofJaco VoorhamPaul DorinskyClaudia CabreraPatrick DarkenJanwillem W H KocksJ Mark FitzGeraldDon D SinVictoria CarterDavid J PricePublished in: International journal of chronic obstructive pulmonary disease (2020)
Patients who experienced a greater exacerbation burden after initiation of maintenance therapy had worse lung function at diagnosis and a more rapid lung function decline thereafter, which emphasizes the need for better treatment strategies.