Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.

Oscar Asanya NyangiriJulius MulindwaJoyce NamulondoAnna KitibwaJacent NassuunaAlison ElliottMagambo Phillip KimudaAlex BooboBarbara NerimaMoses AdrikoNathan J DuntonGaganjit Kaur MadhanMark KristiansenMiriam Casacuberta-PartalHarry NoyesEnock Matovunull null

Published in: PLoS neglected tropical diseases (2023)

Variants associated with S. mansoni worm burden were in IL6, FCN2, RNASE3, IL10, IL12B and IL17B gene loci. However only eQTL associations remained significant after Bonferroni correction. In summary, immune balance, pathogen recognition and Th17 pathways may play a role in modulating Schistosoma worm burden. Individuals carrying risk variants may be targeted first in allocation of control efforts to reduce the burden of schistosomiasis in the community.

Keyphrases

copy number
genome wide
gene expression
risk factors
signaling pathway
cancer therapy