Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages.

Aleksandar Murgaski Máté Kiss Helena Van Damme Daliya Kancheva Isaure Vanmeerbeek Jiri Keirsse Eva Hadadi Jan Brughmans Sana M Arnouk Ahmed E I Hamouda Ayla Debraekeleer Victor Bosteels Yvon Elkrim Louis Boon Sabine Hoves Niels Vandamme Sofie Deschoemaeker Sophie Janssens Abhishek Dinkarnath Garg Greetje Vande Velde Martina Schmittnaegel Carola H Ries Damya Laoui

Published in: Cancer research (2022)

This work highlights the temporal roles of different dendritic cell subsets in promoting CD8+ T-cell-driven responses to CD40 agonist therapy in cancer.

Keyphrases

dendritic cells
peripheral blood
papillary thyroid
nk cells
regulatory t cells
cell cycle
immune response
squamous cell carcinoma
stem cells
young adults
lymph node metastasis