CuCl/Et3N-Catalyzed Synthesis of Indanone-Fused 2-Methylene Pyrrolidines from Enynals and Propargylamines.

Shaotong QiuLianfen ChenHuan-Feng Jiang Shifa Zhu

Published in: Organic letters (2017)

An efficient CuCl/Et3N-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of Et3N was found as the key factor for the success of the tandem reaction.

Keyphrases

room temperature
electron transfer
molecular dynamics
transition metal