Clinical Variables Correlate with Serum Neutralizing Antibody Titers after COVID-19 mRNA Vaccination in an Adult, US-based Population.
Min ZhaoRebecca SlotkinAmar H ShethLauren PischelTassos C KyriakidesBrinda EmuCynthia McNamaraQiaosu ShiJaden DelgobboJin XuElizabeth MarhofferAleagia Mercer-FalkoffJürgen HolleckDavid ArditoRichard E SuttonShaili GuptaPublished in: medRxiv : the preprint server for health sciences (2022)
Multiple clinical factors impact the strength and duration of neutralization response post-primary series vaccination. All subjects, irrespective of prior COVID infection, benefited from a third dose. Malignancy decreased response following third dose, suggesting the importance of clinically guided vaccine regimens.