Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects.
Ricardo Alvarez-JimenezGeert Jan GroeneveldJoop M A van GervenSebastiaan Camiel GouloozeAnne Catrien BaakmanJustin L HayJasper StevensPublished in: British journal of clinical pharmacology (2016)
Most of the differences in response to scopolamine administration between young and older subjects could be explained by pharmacokinetic differences (lower clearance) and not to an enhanced sensitivity when corrected for exposure levels.
Keyphrases