Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics.

Anni M Y ZhangKen H ChuBrian F DalyTitine RuiterYan DouJenny C C YangTwan J J de WinterJustin ChhuorSu WangStephane FlibotteYiwei Bernie ZhaoXiaoke HuHong LiElizabeth J RideoutDavid F SchaefferJames D JohnsonJanel L Kopp

Published in: Cancer & metabolism (2022)

These data suggest a potential role for the immune microenvironment in hyperinsulinemia-driven PanIN development. Together with our previous work, we propose that mild suppression of insulin levels may be useful in preventing pancreatic cancer by acting on multiple cell types.

Keyphrases

single cell
rna seq
stem cells
high throughput
type diabetes
electronic health record
metabolic syndrome
adipose tissue
skeletal muscle
glycemic control
mesenchymal stem cells
artificial intelligence
insulin resistance
weight loss