Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers.
Aaron P SchultzReina W KloetHamid R SohrabiLouise van der WeerdSanneke van RoodenMarieke J H WermerLaure Grand MourselMaqsood YaqubBart N M van BerckelPratishtha ChatterjeeSamantha L GardenerKevin TaddeiAnne M FaganTammie L BenzingerJohn C MorrisReisa SperlingKeith JohnsonRandall J Batemannull nullM Edip GurolMark A van BuchemRalph MartinsJasmeer P ChhatwalSteven M GreenbergPublished in: Annals of neurology (2019)
Increased PiB retention in D-CAA and correlation with reduced CSF Aβ40 suggest this compound labels vascular amyloid, although to a lesser degree than amyloid deposits in ADAD. Progression in PiB signal over time suggests amyloid PET as a potential biomarker in trials of candidate agents for this untreatable cause of hemorrhagic stroke. ANN NEUROL 2019;86:616-625.