Incremental value of serum neurofilament light chain and glial fibrillary acidic protein as blood-based biomarkers for predicting functional outcome in severe acute ischemic stroke.

Christoph VollmuthCornelia FiesslerFelipe A MontellanoAlexander M KollikowskiFabian EssigPatrick OecklLorenzo BarbaPetra SteinackerCara SchulzKathrin UngethümJudith WolfMirko PhamMichael K SchuhmannPeter U HeuschmannKarl Georg HaeuslerGuido StollMarkus OttoHermann Neugebauer

Published in: European stroke journal (2024)

Prediction of functional outcome after severe acute ischemic stroke was improved by the blood-based biomarkers serum NfL and GFAP, measured in the acute phase of stroke. These findings have to be replicated in independent external cohorts.Study registration: DRKS00022064.

Keyphrases

acute ischemic stroke
early onset
atrial fibrillation
cerebrospinal fluid
ionic liquid
drug induced
amino acid
protein protein
binding protein
blood brain barrier