Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences.
Matthijs J V ScheltemaTim J O'BrienWillemien van den BosDaniel M de BruinRafael V DavalosCees W M van den GeldMaria P LagunaRobert E NealIoannis M VarkarakisAndreas SkolarikosPhillip D StrickerTheo M de ReijkeChristopher B ArenaJean de la RosettePublished in: Therapeutic advances in urology (2019)
The electrical field threshold to ablate human prostate tissue in vivo was determined using whole-mount pathology and MRI. These thresholds may be used to develop treatment planning or monitoring software for IRE prostate ablation; however, further optimization of simulation methods are required to decrease the variance that was observed between patients.
Keyphrases
- prostate cancer
- contrast enhanced
- magnetic resonance imaging
- radical prostatectomy
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- endothelial cells
- benign prostatic hyperplasia
- prognostic factors
- magnetic resonance
- stem cells
- computed tomography
- endoplasmic reticulum stress
- patient reported outcomes
- combination therapy
- radiofrequency ablation
- genetic diversity