Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE.

Xiao HuShirong LiDesislava Met DoychevaLei HuangCameron LenahanRui LiuJuan HuangShucai XieJiping TangGang ZuoArne P Neyrinck

Published in: Journal of neuroinflammation (2020)

Our findings demonstrated that the activation of CSF1R by rh-CSF1 attenuated neuroinflammation and improved neurological deficits after HI. The anti-inflammatory effects of rh-CSF1 partially acted through activating the CSF1R/PLCG2/PKCε/CREB signaling pathway after HI. These results suggest that rh-CSF1 may serve as a potential therapeutic approach to ameliorate injury in HIE patients.

Keyphrases

signaling pathway
traumatic brain injury
cerebrospinal fluid
end stage renal disease
anti inflammatory
ejection fraction
cognitive impairment
pi k akt
lps induced
cell proliferation
cerebral ischemia
peritoneal dialysis
endoplasmic reticulum stress
subarachnoid hemorrhage
patient reported