DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway.

J LinB LiQ XuY S LiuY L KangX WangY WangY LeiY L BaiX M LiJie Zhou

Published in: Journal of endocrinological investigation (2023)

This study proved that sPA presents a risk factor for kidney injuries and DACH1 might serve as a protective target against renal function deterioration in diabetic patients.

Keyphrases

high glucose
toll like receptor
transforming growth factor
signaling pathway
nuclear factor
inflammatory response
epithelial mesenchymal transition
immune response
lps induced
diabetic rats
oxidative stress