Race, Genetic Ancestry, and Estimating Kidney Function in CKD.
Chi-Yuan HsuWei YangRishi V ParikhAmanda H AndersonTeresa K ChenDebbie L CohenJiang HeMadhumita J MohantyJames P LashKatherine T MillsAnthony N MuiruAfshin ParsaMilda R SaundersTariq ShafiRaymond R TownsendSushrut S WaikarJianqiao WangMyles WolfThida C TanHarold I FeldmanAlan S Gonull nullPublished in: The New England journal of medicine (2021)
The use of the serum creatinine level to estimate the GFR without race (or genetic ancestry) introduced systematic misclassification that could not be eliminated even when numerous non-GFR determinants of the serum creatinine level were accounted for. The estimation of GFR with the use of cystatin C generated similar results while eliminating the negative consequences of the current race-based approaches. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others.).