N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction.
Maria Buur Nordskov GabeLaerke Smidt GasbjergSarina GadgaardPeter LindquistJens Juul HolstMette Marie RosenkildePublished in: British journal of pharmacology (2022)
The N-terminus of GLP-2 is crucial for GLP-2R activity and selectivity. Our observations form the basis for the development of tool compounds for further characterization of the GLP-2 system.
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