Potential mechanism for hyperhomocysteinemia in Greyhound dogs.
Kelsey L JohnsonTorrey TiedemanHannah PetersonJoerg M SteinerLauren A TrepanierPublished in: Journal of veterinary internal medicine (2023)
Our findings suggest a primary defect in conversion of HCy to methionine in Greyhounds, with related impaired folate generation. Ineffective cycling by methionine synthase could lead to secondary cobalamin depletion. Notably, low serum folate and cobalamin concentrations can be observed in Greyhounds without signs of intestinal disease.