Inhibition of BETs prevents heat shock-induced cell death via upregulating HSPs in SV40 large T antigen transfected cells.

Nan ZhouYe ZhangGongyun LeiYifan ChenTing LinQin LiuYinshuang ZhaoJiahui MaoYongying JiangRenfang Mao

Published in: Genes & genomics (2022)

Inhibition of BETs by JQ1 and I-BET-762 prevents heat shock-induced cell death via upregulating HSPs in SV40 large T antigen transfected cells. Our data indicate a novel function of BETs in SV40 large T antigen transformed cells, affecting HSPs and HSF1 as well as its function on heat shock response.

Keyphrases

heat shock
cell cycle arrest
cell death
heat stress
induced apoptosis
heat shock protein
oxidative stress
diabetic rats
high glucose
endoplasmic reticulum stress
signaling pathway
mouse model
electronic health record
endothelial cells
deep learning