Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.

Viviana CasagrandeAlessandro MaurielloLucia AnemonaMaria MavilioGiulia IulianiLorenzo De AngelisMara D'OnofrioIvan ArisiMassimo FedericiRossella Menghini

Published in: Acta diabetologica (2019)

This study suggests that Timp3 ablation leads to cell cycle perturbation, at least in part by repressing FoxM1 transcriptional activity through H19/miR-675/p53 pathway.

Keyphrases

cell cycle
high fat diet induced
cell proliferation
metabolic syndrome
type diabetes
weight loss
transcription factor
physical activity
adipose tissue
body mass index
atrial fibrillation
radiofrequency ablation