Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

Toshiya Nishi Cameron S MetcalfShinji FujimotoShigeo HasegawaMaki MiyamotoEiji SunaharaSayuri WatanabeShinichi KondoH Steve White

Published in: Epilepsia (2022)

The data collectively suggest that soticlestat can ameliorate seizure symptoms through a mechanism distinct from conventional antiseizure medications. With its novel mechanism of action, soticlestat could constitute a novel class of antiseizure medications for treatment of intractable epilepsy disorders such as developmental and epileptic encephalopathy.

Keyphrases

early onset
electronic health record
low density lipoprotein
depressive symptoms
physical activity
deep learning