Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation.

Yingfei LiYi HeFangyuan YangRongmei LiangWenchao XuYehao LiJingbo ChengBaozhu LiangMing TangXingliang ShiJian ZhuangMinshuang LuoLiuying LiRuilin ZhangHuijuan LiuHongyu JieXing LiXinai HanErwei SunZeqing Zhai

Published in: The British journal of dermatology (2024)

Our study provides a novel explanation of TNF-α/caspase-3/GSDME-mediated keratinocyte pyroptosis in the initiation and -acceleration of skin inflammation and the progression of psoriasis.

Keyphrases

oxidative stress
nlrp inflammasome
soft tissue
wound healing
rheumatoid arthritis
cell death
induced apoptosis
atopic dermatitis