Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: an observational study.

Our study confirms the use of levetiracetam as suitable antiepileptic drug in pregnancy. The lower birth weight of male neonates after maternal levetiracetam monotherapy and the unexpectedly high risk for spontaneous abortion and birth defects after dual therapy with levetiracetam and lamotrigine require further investigation.