Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe.

Bernard NgaraSimbarashe ZvadaTariro Dianah ChawanaCharles Fungai Brian NhachiSimbarashe Rusakaniko

Published in: BMC pharmacology & toxicology (2021)

Atazanavir in hair in the range 2.6 to 4.5 ng/mg is associated with above 50% probability of early viral load suppression. Adherence monitoring to adolescents with lower potency of atazanavir is recommended. The effect self-reported adherence level, BMI-for-age, and caregiver status require further evaluation.

Keyphrases

hiv infected patients
antiretroviral therapy
young adults
hiv infected
physical activity
human immunodeficiency virus
body mass index
hiv positive
hiv aids
weight gain
adipose tissue
hepatitis c virus
men who have sex with men
hiv testing
insulin resistance