Mitochondrial homeostasis in adipose tissue remodeling.
Svetlana Altshuler-KeylinShingo KajimuraPublished in: Science signaling (2017)
Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy that degrades mitochondria, plays a key role in the physiology and pathophysiology of mitochondria-enriched cells, such as brown and beige adipocytes. This review discusses findings regarding the roles of autophagy and mitophagy in cellular development, maintenance, and functions of metabolic organs, including adipose tissue, liver, and pancreas. A better understanding of the molecular links between mitophagy and energy metabolism will help to identify promising targets for the treatment of obesity and obesity-associated disorders.
Keyphrases
- adipose tissue
- insulin resistance
- oxidative stress
- cell death
- induced apoptosis
- cell cycle arrest
- high fat diet induced
- metabolic syndrome
- high fat diet
- endoplasmic reticulum stress
- weight loss
- type diabetes
- nlrp inflammasome
- signaling pathway
- weight gain
- reactive oxygen species
- body mass index
- combination therapy
- cell proliferation
- physical activity
- single molecule