Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis.
Kristin P O'GradyAdrienne N DulaBailey D LyttleLindsey M ThompsonBenjamin N ConradBailey A BoxLydia J McKeithanSiddharama PawateFrancesca BagnatoBennett A LandmanPaul NewhouseSeth A SmithPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)
Glutamate-sensitive contrast was significantly increased in the prefrontal cortex of MS patients with accumulated disability (p < 0.05). In addition, glutamate-sensitive contrast in the prefrontal cortex was significantly correlated with symbol digit modality test (rS = -0.814) and choice reaction time (rS = 0.772) scores in patients (p < 0.05), suggesting that GluCEST MRI may have utility as a marker for GM pathology and CI.
Keyphrases
- prefrontal cortex
- multiple sclerosis
- cognitive impairment
- contrast enhanced
- end stage renal disease
- magnetic resonance
- ejection fraction
- newly diagnosed
- chronic kidney disease
- magnetic resonance imaging
- mass spectrometry
- high resolution
- prognostic factors
- ms ms
- computed tomography
- photodynamic therapy
- diffusion weighted imaging