SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model.
Laura BonfiliValentina CecariniMassimiliano CuccioloniMauro AngelettiSara BerardiSilvia ScarponaGiacomo RossiAnna Maria EleuteriPublished in: Molecular neurobiology (2018)
The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the treatment of CNS-associated disorders. In this study, we explored the properties of a probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer's disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated with SLAB51 and the effects on protein oxidation, neuronal antioxidant defence and repair systems were monitored, with the particular focus on the role of SIRT1-related pathways. We demonstrated that SLAB51 markedly reduced oxidative stress in AD mice brain by activating SIRT1-dependent mechanisms, thus representing a promising therapeutic adjuvant in AD treatment.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- mouse model
- resting state
- white matter
- cerebral ischemia
- blood brain barrier
- drug delivery
- functional connectivity
- diabetic rats
- early stage
- high fat diet induced
- signaling pathway
- type diabetes
- dna damage
- combination therapy
- adipose tissue
- small molecule
- wild type
- subarachnoid hemorrhage
- heat stress
- insulin resistance
- protein protein