A novel pentacyclic triterpene from the canes of Uncaria sessilifructus (Rubiaceae).

Qingfei FanZhi NaKailong JiPianchou GongpanLan ZhouWenqian HeFengmei HuangHuabin HuQishi Song

Published in: Natural product research (2020)

One novel pentacyclic triterpene, 24-dimethoxymethyl-3β,6β,19α- trihydroxy -12-en-28-oic acid (1), along with six known compounds 2-7, were isolated from the canes of Uncaria sessilifructus Roxb. Their structures were determined according to spectroscopic and spectrometric analysis. The anti-inflammatory activities of the isolated compounds (1-7) were scanned against NO production in LPS-activated RAW 264.7 macrophages by MTS assay, however no activities were observed.

Keyphrases

anti inflammatory
molecular docking
inflammatory response
high throughput
high resolution
mass spectrometry
molecular dynamics simulations
tandem mass spectrometry