Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation.

Tomoyuki Watanabe Hirotsugu Miyoshi Yuko Noda Soshi Narasaki Atsushi Morio Yukari Toyota Hiroshi Yokomi Keiko Mukaida Toshimichi Yasuda Yasuo M Tsutsumi

Published in: BioMed research international (2021)

The increase in intracellular Ca2+ concentration caused by remimazolam or propofol was not considered an RYR1-mediated reaction. We conclude that remimazolam and propofol can be safely used as an anesthetic in MH-susceptible patients with RYR1-mutation without causing MH and may be safely substituted for an MH-triggering anesthetic when RYR1-mediated MH occurs.

Keyphrases

molecular docking
protein kinase