Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.

Jessica H HartmanClaudia Gonzalez-HuntSamantha M HallIan T RydeKim A CaldwellGuy A CaldwellJoel N Meyer

Published in: International journal of molecular sciences (2019)

Together, our results support a strong role for gene by environment interactions in driving dopaminergic neurodegeneration and suggest that genetic deficiency in mitochondrial processes can have complex effects on neurodegeneration.

Keyphrases

genome wide
copy number
oxidative stress
diabetic rats
dna methylation
drug induced
radiation therapy
smoking cessation