Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury.
Fabiola Bezerra de Carvalho MacruzFabrício Stewan FeltrinAna ZaninottoVinícius Monteiro de Paula GuiradoMaria Concepcion Garcia OtaduyMiriam Harumi TsunemiMariana Penteado NucciCarolina RimkusCeli Santos AndradeClaudia da Costa LeitePublished in: Brain and behavior (2022)
A progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients' episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.
Keyphrases
- white matter
- working memory
- end stage renal disease
- multiple sclerosis
- spinal cord injury
- chronic kidney disease
- newly diagnosed
- traumatic brain injury
- prognostic factors
- public health
- peritoneal dialysis
- mild cognitive impairment
- resting state
- functional connectivity
- patient reported outcomes
- blood brain barrier
- brain injury