Vascular heterogeneity: VEGF receptors make blood vessels special.

Published in: The Journal of experimental medicine (2022)

Karaman et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210565) examined the differential effects of the conditional deletion of genes encoding each VEGF receptor, VEGFR1, VEGFR2 and VEGFR 3, as well as combinations thereof in mice. The results highlight the crosstalk between receptors in different organs and emphasize the importance of VEGF receptor expression and interplay in vascular heterogeneity.

Keyphrases

vascular endothelial growth factor
endothelial cells
single cell
genome wide
type diabetes
high fat diet induced
gene expression
metabolic syndrome
bioinformatics analysis