Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.
Stephanie DufekChris CheshireAdam P LevineRichard S TrompeterNaomi IsslerMatthew StubbsMonika MozereSanjana GuptaEnriko KlootwijkVaksha PatelDaljit HothiAoife WatersHazel WebbKjell TullusLucy JenkinsLighta GodinhoElena LevtchenkoJack WetzelsNine KnoersNynke TeeningaJeroen NautaMohamed ShalabySherif EldesokyJameela A KariShenal ThalgahagodaRandula RanawakaAsiri AbeyagunawardenaAdebowale AdeyemoMark KristiansenRasheed A GbadegesinNicholas J WebbDaniel P GaleHoria C StanescuRobert KletaDetlef BockenhauerPublished in: Journal of the American Society of Nephrology : JASN (2019)
Because CALHM6 is implicated in regulating the immune response to infection, this may provide an explanation for the typical triggering of SSNS onset by infections. Our results suggest that a genetically conferred risk of immune dysregulation may be a key component in the pathogenesis of SSNS.
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