Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis.

Milena PawAgnieszka A KusiakKinga NitJacek J LitewkaMarcin PiejkoDawid WnukMichał SarnaKinga FicKinga B StopaRuba HammadOlga Barczyk-WoznickaToni CathomenEwa Zuba-SurmaZbigniew MadejaPaweł E FerdekSylwia Bobis-Wozowicz

Published in: BMC medicine (2023)

In this work, we provide evidence of superior anti-fibrotic properties of EV-H5 over EV-N or EV-H3. Our study uncovers that fine regulation of oxygen concentration in the cellular environment may enhance the anti-fibrotic effects of hiPS-EVs, which has great potential to be applied for heart regeneration.

Keyphrases

systemic sclerosis
idiopathic pulmonary fibrosis
transforming growth factor
stem cells
heart failure
epithelial mesenchymal transition
air pollution
atrial fibrillation
risk assessment
climate change
pulmonary fibrosis