Cathepsin B inhibition ameliorates leukocyte-endothelial adhesion in the BTBR mouse model of autism.

Huan WangYi-Xuan YinDong-Mei GongLing-Juan HongGang WuQuan JiangCheng-Kun WangPablo BlinderSen LongFeng Han Ying-Mei Lu

Published in: CNS neuroscience & therapeutics (2018)

Our results revealed the prominent role of cathepsin B in modulating leukocyte-endothelial adhesion during autism-related neurovascular inflammation and identified a promising novel approach for autism treatment.

Keyphrases

autism spectrum disorder
intellectual disability
mouse model
endothelial cells
oxidative stress
biofilm formation
peripheral blood
signaling pathway
single cell
cell migration
escherichia coli
staphylococcus aureus