Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats - comparisons with males.
Mimmi RehnströmSimona Denise FrederiksenSaema AnsarLars EdvinssonPublished in: BMC genomics (2020)
The cascades of processes initiated in the vasculature following reperfusion are complex. Dynamic gene expression alterations were observed in the occluded MCAs, and to a less pronounced degree in the non-occluded MCAs. Dysregulation of inflammation and blood-brain barrier breakdown are possible pharmacological targets. The sample of genes (< 1% of the differentially expressed genes) validated for this microarray did not reveal any sex differences. However, sex differences might be observed for other gene targets.
Keyphrases
- genome wide
- blood brain barrier
- single cell
- smooth muscle
- dna methylation
- genome wide identification
- gene expression
- cerebral ischemia
- rna seq
- copy number
- genome wide analysis
- bioinformatics analysis
- oxidative stress
- transcription factor
- acute myocardial infarction
- atrial fibrillation
- subarachnoid hemorrhage
- stem cells
- acute ischemic stroke
- brain injury
- acute coronary syndrome
- coronary artery disease