Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma.
Taciani de Almeida MagalhãesGustavo Alencastro Veiga CruzeiroGraziella Ribeiro de SousaBernhard EnglingerLuis Fernando Peinado NaganoMathew AncliffeKeteryne Rodrigues da SilvaLi JiangJohannes GojoYulu Cherry LiuBrooke CarlineMani KuchibhotlaFabiano Pinto SaggioroSuely Kazue Nagahashi MarieSueli Mieko Oba-ShinjoJosé Andres YunesRosane Gomes de Paula QueirozCarlos Alberto ScrideliRaelene EndersbyMariella G FilbinKleiton Silva BorgesAdrian SalicLuiz Gonzaga ToneElvis Terci ValeraPublished in: Neuro-oncology (2022)
Our study reveals a crucial role for the Hh pathway in ST-RELA tumor growth, and suggests that rescue of primary cilia represents a vulnerability of the ST-RELA EPNs.
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