DNA Methylation as a Potential Molecular Mechanism in X-linked Dystonia-Parkinsonism.
Christin KrauseSusen SchaakeKaren GrützHelen SievertCharles Jourdan ReyesInke R KönigBjörn-Hergen LaabsRoland Dominic JamoraRaymond L RosalesCid Czarina E DiestaJelena PozojevicTimo GemollAna WestenbergerFrank J KaiserChristine KleinHenriette KirchnerPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
We identified altered DNA methylation in X-linked dystonia-parkinsonism patients as a possible additional mechanism modulating TAF1 expression and putative novel targets for future therapies using DNA methylation-modifying agents. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- dna methylation
- genome wide
- gene expression
- deep brain stimulation
- end stage renal disease
- parkinson disease
- early onset
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- prognostic factors
- drug induced
- copy number
- signaling pathway
- systematic review
- risk assessment
- patient reported outcomes
- human health
- current status
- meta analyses