Rosa canina extract relieves methylation alterations of pancreatic genes in STZ-induced diabetic rats : Gene methylation in diabetic rats treated with an extract.
Hadis JavidSoraya SajadimajdMohammadTaher BahramiGholamreza BahramiBahareh MohammadiSaeed KhazayelSeyed Shahram MiraghaeePublished in: Molecular biology reports (2024)
The results of this study showed that Rosa canina extract as a spray-dried sample could be effective in treating diabetes by regulating the methylation of genes including Pdx-1, Pax-4, and Ins-1 involved in the activity and regeneration of pancreatic islet cells.
Keyphrases
- diabetic rats
- oxidative stress
- genome wide
- induced apoptosis
- dna methylation
- genome wide identification
- copy number
- stem cells
- type diabetes
- cardiovascular disease
- cell cycle arrest
- anti inflammatory
- genome wide analysis
- metabolic syndrome
- endoplasmic reticulum stress
- cell proliferation
- bioinformatics analysis
- insulin resistance
- gene expression
- signaling pathway
- pi k akt
- high glucose