Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.
Hazel WilkieMrinmoy DasTyler PelovitzWayne BainterBrian WoodsMohammed AlashareeAli SobhSafa BarisSevgi Bilgic EltanWaleed Al-HerzMohamed-Ridha BarboucheImen Ben-MustaphaMeriem Ben-AliMohamed T H SallamAmany AwadSohilla LotfyAisha El MarsafyMoushira EzzelarabMichael FarrarBrigitta A R SchmidtMonali NandyMazumdarEmma Guttman-YasskyAnthony SheetsKatie Maria VidicGeorge MurphyPatrick M SchlievertJanet ChouJuan Manuel Leyva-CastilloErin JanssenMaheshwor TimilshinaRaif S GehaPublished in: The Journal of allergy and clinical immunology (2024)
Treg cell dysfunction increases susceptibility to allergic skin inflammation in DOCK8 deficiency and synergizes with cutaneous exposure to Saureus to drive eczema in DOCK8 deficiency.