COVID-19 versus Other Disease Etiologies as the Cause of ARDS in Patients Necessitating Venovenous Extracorporeal Membrane Oxygenation-A Comparison of Patients' Data during the Three Years of the COVID-19 Pandemic.
Sua KimHyeri SeokBeong Ki KimJinwook HwangDae Won ParkJae Seung ShinJe Hyeong KimPublished in: Journal of clinical medicine (2023)
Considering the characteristics of coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS), we compared the clinical course and outcomes of patients with ARDS who received venovenous extracorporeal membrane oxygenation (VV ECMO) based on the etiology of ARDS. This retrospective single-center study included adult patients with severe ARDS necessitating VV ECMO during the COVID-19 pandemic. Among 45 patients who received VV ECMO, 21 presented with COVID-19. COVID-19 patients exhibited lower sequential organ failure assessment scores (9 [8-12.75] versus 8 [4-11.5], p = 0.033) but longer duration of VV ECMO support (10.5 days [3.25-29.25] versus 28 days [10.5-70.5] p = 0.018), which was accompanied by an weaning off rate from VV ECMO in 12/24 (50%) versus 12/21 (57.1%) and 28-day mortality in 9/24 [37.5%] versus 2/21 [9.5%] in non-COVID-19 and COVID-19 patients ( p = 0.767, p = 0.040), respectively. Finally, in the adjusted Cox regression model for hospital mortality, the hazard ratio of COVID-19 was not significant (hazard ratio 0.350, 95% confidence interval 0.110-1.115, p = 0.076). Although the VV ECMO period was longer, COVID-19 did not significantly impact ECMO weaning off and mortality rates. Nonetheless, judicious patient selections based on risk factors should be followed.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- coronavirus disease
- sars cov
- mechanical ventilation
- respiratory failure
- risk factors
- respiratory syndrome coronavirus
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cardiovascular events
- healthcare
- prognostic factors
- type diabetes
- emergency department
- cardiovascular disease
- insulin resistance
- electronic health record
- patient reported outcomes