Anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors in COVID-19.
Habib YaribeygiMina MalekiStephen L AtkinPrashant KesharwaniTannaz JamialahmadiAmir Hossein SahebkarPublished in: IUBMB life (2023)
The ongoing pandemic of COVID-19 is intrinsically a systemic inflammatory disorder; hence, those patients suffering an underlying chronic inflammatory disease such as diabetes mellitus are at high risk of severe complications. Preventing or suppressing the inflammatory responses are of importance in diabetic patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are a newly introduced anti-diabetic drugs that have hypoglycemic effects through the urinary excretion of glucose. They also have an anti-inflammatory potential in diabetes patients, in addition to improving glycemic control, and while there is no direct data available in diabetic patients with COVID-19 disease, there is evidence that suggests that SGLT2i can reduce systemic inflammation and diminish the cytokine storm effect via several cellular mechanisms. In the current review, our aim was to classify and describe the molecular and cellular pathways by which SGLT2i have anti-inflammatory effects in diabetic patients with COVID-19 disease.
Keyphrases
- type diabetes
- glycemic control
- coronavirus disease
- end stage renal disease
- sars cov
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cardiovascular disease
- prognostic factors
- anti inflammatory
- oxidative stress
- signaling pathway
- adipose tissue
- blood pressure
- artificial intelligence
- deep learning
- climate change
- electronic health record
- weight loss
- data analysis