Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis.

Roxane RohaniBrian HoffManu JainAlexander PhilbrickSara SalamaJoanne F CullinaNathaniel James Rhodes

Published in: European journal of drug metabolism and pharmacokinetics (2021)

Exposure-matching maintained PTA at MICs ≤ 1 mg/l while reducing toxicity risk in older patients compared to fixed dosing. Confirmatory studies are needed.

Keyphrases

pseudomonas aeruginosa
oxidative stress
case control
acinetobacter baumannii
emergency department
drug induced
multidrug resistant
drug resistant