MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration.
Thomas WallachZoé J MossmannMichal SzczepekMax WetzelRui MachadoMartin RadenMilad MiladiGunnar KleinauChristina KrügerPaul DembnyDrew AdlerYuanyuan ZhaiVictor KumbolOmar DzayeJutta SchülerMatthias FutschikRolf BackofenPatrick ScheererSeija LehnardtPublished in: Molecular neurodegeneration (2021)
Our data demonstrate that specific miRNAs are released from apoptotic cortical neurons, serve as endogenous TLR7/8 ligands, and thereby trigger further neuronal apoptosis in the CNS. Our findings underline the recently discovered role of miRNAs as extracellular signaling molecules, particularly in the context of neurodegeneration.
Keyphrases
- toll like receptor
- cell death
- cell cycle arrest
- inflammatory response
- nuclear factor
- spinal cord
- immune response
- anti inflammatory
- oxidative stress
- electronic health record
- endoplasmic reticulum stress
- blood brain barrier
- cerebral ischemia
- spinal cord injury
- cell proliferation
- signaling pathway
- brain injury
- machine learning
- data analysis
- subarachnoid hemorrhage