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Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis.

Katerina KachlerDarja AndreevShreeya ThapaDmytro RoyzmanAndreas GießlShobika KaruppusamyMireia Llerins PerezMengdan LiuJörg HofmannArne GessnerXianyi MengSimon RauberAlexander SteinkassererMartin FrommLarissa Valor-MéndezAline Bozec
Published in: Annals of the rheumatic diseases (2024)
Acod1 and itaconate are crucial regulators of osteoclast differentiation and bone loss in inflammatory arthritis.
Keyphrases
  • bone loss
  • rheumatoid arthritis
  • oxidative stress
  • signaling pathway
  • transcription factor
  • high intensity
  • bone mineral density