Methylation of NRIP3 Is a Synthetic Lethal Marker for Combined PI3K and ATR/ATM Inhibitors in Colorectal Cancer.

Meiying ZhangXiaoyun LiJames G HermanAiai GaoQian WangYuanxin YaoFangfang ShenKunlun HeMingzhou Guo

Published in: Clinical and translational gastroenterology (2024)

NRIP3 was frequently methylated in both colorectal adenomatous polyps and CRC. The methylation of NRIP3 may potentially serve as an early detection, late-onset, and poor prognostic marker in CRC. NRIP3 is a potential tumor suppressor. NRIP3 methylation is a potential synthetic lethal marker for combined PI3K and ATR/ATM inhibitors.

Keyphrases

late onset
dna damage response
genome wide
dna methylation
early onset
dna damage
dna repair
human health
gene expression
risk assessment